Synthesis of 3,4-dihydropyrimidin-2(1H)-ones using Ziegler–Natta catalyst system under solvent free conditions

✍ Scribed by Atul Kumar; Ram Awatar Maurya

• Book ID: 104057227
• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 164 KB
• Volume: 272
• Category: Article
• ISSN: 1381-1169
• DOI: 10.1016/j.molcata.2007.03.026

✦ Synopsis

A Ziegler-Natta catalyst system (TiCl 4 -MgCl 2 /magnesium chloride-methanol adduct) was efficiently found to catalyze the three component Biginelli reaction of an aldehyde, ␤-keto ester, and urea or thiourea under solvent free conditions to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones in excellent yields. The enhanced surface areas of TiCl 4 -MgCl 2 -methanol adduct plays significant role in providing an efficient synthesis of Biginelli compounds.