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Efficient Synthesis of 3-Chloromethyl-2(5 H )-furanones and 3-Chloromethyl- 5,6-dihydropyran-2-ones via the PdCl 2 -Catalyzed Chlorocyclocarbonylation of 2,3- or 3,4-Allenols

✍ Scribed by Cheng, Xin; Jiang, Xuefeng; Yu, Yihua; Ma, Shengming


Book ID
120342932
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
208 KB
Volume
73
Category
Article
ISSN
0022-3263

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Efficient synthesis of 4-(2β€²-alkenyl)-2,
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4-(2%-Alkenyl)-2,5-dihydrofurans can be efficiently synthesized via the PdCl 2 -catalyzed coupling-cyclization of allylic halides with 2,3-allenols in DMA at rt in moderate to good yields. The regioselectivity is different from that of the Pd(0)-catalyzed coupling-cyclization of organic halides with