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Efficient Synthesis of 2-Fluoromethylated Quinolines via Copper-Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides

✍ Scribed by Shan Li; Yafen Yuan; Jiangtao Zhu; Haibo Xie; Zixian Chen; Yongming Wu

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
165 KB
Volume
352
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

2‐Fluoromethylated quinolines were synthesized through the reaction of N‐aryl‐fluorinated imidoyl iodides with terminal alkynes in good yields by the catalysis of copper(I) iodide (CuI) alone.

📜 SIMILAR VOLUMES

ChemInform Abstract: Efficient Synthesis
ChemInform Abstract: Efficient Synthesis of 2-Fluoromethylated Quinolines via Copper-Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides.
✍ Shan Li; Yafen Yuan; Jiangtao Zhu; Haibo Xie; Zixian Chen; Yongming Wu 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 1 views

## Abstract An efficient one‐pot synthesis of fluoroalkyl‐substituted quinolines is presented, involving the Cu‐catalyzed alkynylation of fluoroalkylimidoyl iodides (I) and (IV) and subsequent cyclization.