## Abstract 2‐Fluoromethylated quinolines were synthesized through the reaction of __N__‐aryl‐fluorinated imidoyl iodides with terminal alkynes in good yields by the catalysis of copper(I) iodide (CuI) alone.
ChemInform Abstract: Efficient Synthesis of 2-Fluoromethylated Quinolines via Copper-Catalyzed Alkynylation and Cyclization of Fluorinated Imidoyl Iodides.
✍ Scribed by Shan Li; Yafen Yuan; Jiangtao Zhu; Haibo Xie; Zixian Chen; Yongming Wu
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
An efficient one‐pot synthesis of fluoroalkyl‐substituted quinolines is presented, involving the Cu‐catalyzed alkynylation of fluoroalkylimidoyl iodides (I) and (IV) and subsequent cyclization.
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