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Efficient Synthesis of 14C-Labeled 1H-Pyrazolo[3,4-d]pyrimidine and Related [4.3.0]-Bicyclic Pyrimidino Systems

✍ Scribed by Jonathan Z. Ho; Kyle R. Van Arsdale; Matthew P. Braun

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
174 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

In support of a research program aimed at discovering purine‐related anticancer drug candidates, a method for the ^14^C‐labeling of pyrazolopyrimidines utilizing the readily available labeled starting material, sodium [^14^C]formate, has been developed with a good overall yield. This new method was proven to be general in the preparation of other related [4.3.0]heterocycles containing N, O, and S atoms. A concise synthesis of a model compound, 8‐aza‐7‐deaza‐5′‐[^14^C]noraristeromycin, was achieved utilizing this methodology as a key step.

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