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A new regioselective synthesis and bioactivity of 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives

✍ Scribed by Hong-Qing Wang; Zhao-Jie Liu; Li-Min Yang; Ming-Wu Ding

Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
154 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of new 1__H__‐pyrazolo[3,4‐d]pyrimidin‐4(5H)‐one Derivatives 5 has been designed and regio‐selectively synthesized via a tandem aza‐Wittig reaction. The structures of all compounds prepared have been confirmed by ^1^H NMR, IR, EI‐MS spectroscopy and elemental analyses. The results of preliminary bioassay indicate that most compounds 5 possess an inhibition effect against Botrytis cinereapers and Pyricularia oryzae at the concentration of 50 mg/L.

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