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Efficient synthesis of 13C-labelled erythromycin biosynthetic intermediate. 1: S-2-acetylaminoethyl (2R,3R,4R,5R)-3,5-diacetoxy-2,4-dimethyl-4-([13C]methoxy)-heptanethioate

✍ Scribed by Katsumi Iida; Masahiro Kajiwara; Tomoko Inoue-Tanihata; Mineo Fukui; Tadashi Nakata; Takeshi Oishi

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
149 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An efficient ^13^C‐labelling synthesis of the putative erythromycin biosynthetic intermediate, S‐2‐acetylaminoethyl (2__R__,3__R__,4__R__,5__R__)‐3,5‐diacetoxy‐2,4‐dimethyl‐4‐([^13^C]methoxy)heptanethioate, which would be useful for the investigation of the chain elongation mechanism in erythromycin biosynthesis, was achieved by utilizing iodo[^13^C]methane and (2__S__,3__R__,4__R__,5__R__)‐4‐hydroxy‐3,5‐O‐isopropylidene‐2,4‐dimethylheptanol, obtained in our previous studies on erythromycin A synthesis. Copyright © 2008 John Wiley & Sons, Ltd.

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