Water / α-Nitrocycloalkanones / ω-Nitro acids / Surfactant The reaction of various α-nitrocycloalkanones 1 with of the latter with HCOONH 4 /Pd-C, in methanol, at 80 °C affords ω-amino acids 3. The synthesis of methyl 9-aqueous 0.05 M NaOH, at 80 °C, in the presence of cetyltrimethylammonium chlori
Efficient Syntheses of ω-Trifluoromethyl Substituted ω-Amino Acids.
✍ Scribed by Natalia N. Sergeeva; Alexander S. Golubev; Lothar Hennig; Klaus Burger
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 163 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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A series of ω-trans-(bicyclopropyl)-substituted fatty acids 9 has been synthesized from bicyclopropylidene (5) starting by deprotonation with n-butyllithium. Electrophilic substitution of lithiobicyclopropylidene with THP-protected ω-iodoalkanols 6 gave the THP-protected (bicyclopropylidenyl)alkanol
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