Oligoribonucleotides, six to fifteen units long, were synthesized on a controlled pore glass support using ribonucleoside 3'-0-phosphoramidite reagents. Average coupling yieids of up to 98% were obtained with dirsopropylamrnophosphoramidite derivatives. In light of the increasing interest in the ro
β¦ LIBER β¦
Efficient Solid-Phase Synthesis of Trifunctional Probes and Their Application to the Detection of Carbohydrate-Binding Proteins
β Scribed by Lee, Myung-ryul; Jung, Da-Woon; Williams, Darren; Shin, Injae
- Book ID
- 126242100
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 270 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1523-7060
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The N a aC a H exchange in aza-peptides has the advantage of preserving the side chain. Bis(trichloromethyl)carbonate or triphosgene is a solid, stable phosgene substitute which retains its high reactivity. Temperature and coupling times are greatly reduced with reference to other usually recommende