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Efficient solid phase peptide synthesis

✍ Scribed by KISO, YOSHIAKI ;FUJIWARA, YOICHI ;KIMURA, TOORU ;NISHITANI, AKIKO ;AKAJI, KENICHI


Book ID
115099324
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
588 KB
Volume
40
Category
Article
ISSN
0367-8377

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Simple and efficient solid-phase synthes
✍ Dominique LeliΓ¨vre; Hadjila Chabane; AgnΓ¨s Delmas πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 217 KB

We describe an efficient solid-phase synthesis of C-terminal peptide aldehyde. Making use of the stability of the PAM linker towards both acid and base conditions, a pentapeptide was synthesized starting from a PAM resin according to Fmoe/tBu chemistry. The side-chains were deprotected by TFA. The p