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Efficient Sialyltransferase Inhibitors Based on Glycosides of N -Acetylglucosamine

✍ Scribed by Schwörer, Ralf; Schmidt, Richard R.

Book ID
126783831
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
106 KB
Volume
124
Category
Article
ISSN
0002-7863

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📜 SIMILAR VOLUMES

Efficient Sialyltransferase Inhibitors B
Efficient Sialyltransferase Inhibitors Based on Transition-State Analogues of the Sialyl Donor
✍ Bernd Müller; Christoph Schaub; Richard R. Schmidt 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 161 KB 👁 2 views

A 200- to 1000-fold higher affinity for sialyltransferase is shown by compounds 1 and 2 relative to the natural substrate. These inhibitors, which are derived from the transition state of S 1-type sialyltransfer, contain a flat ring that is attached through a carbon atom with a phosphonate and a cyt