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Efficient Regioselective Synthesis of 6-Amino-5-benzoyl-1-Substituted 2(1H)-Pyridinones.

✍ Scribed by Hartmut Schirok; Cristina Alonso-Alija; Jordi Benet-Buchholz; Andreas H. Goeller; Rolf Grosser; Martin Michels; Holger Paulsen


Publisher
John Wiley and Sons
Year
2006
Weight
41 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Synthesis of Substituted 2-Amino-6H-1,3-
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Synthesis of 6-Substituted-3-hydroxy-4(1H)-pyridinones: Oxidation-Michael Addition of 3-Hydroxy-4(1H)-pyridinones. -The oxidation of pyridinones of type (I) with Ag 2 O involving alcohols (II) is reported for the first time. The resulting pyridinediones subsequently undergo Michael addition with thi

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## Abstract Syntheses of 2‐aryloxy/2‐chloro ethoxy‐2,3‐dihydro‐5‐benzoyl‐1H‐1,3,2‐benzodiaza‐phosphole 2‐oxides **3a–h** were accomplished by reactions of equimolar quantities of 3,4‐diaminobenzophenone (**1**) with various aryl/chloroethoxy phosphorodichloridates **2a–g** and **2h** in the presenc