Chemical asymmetric syntheses of the key intermediates (4,6,8) for the \_\_ synthesis of monobactam antibiotics ( SQ 26776 (azthreonam), sulfazecin, and SQ 26180 ) are accomplished from I\*)-4-phenylsulfonyl-2-azetidinone. Recently much attention have been focused on the nonclassical B-lactam antibi
Efficient Oxidizing Methods for the Synthesis of Oxandrolone Intermediates.
โ Scribed by Sandeep K. Ginotra; Bhupender S. Chhikara; Manish Singh; Ramesh Chandra; Vibha Tandon
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 146 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The tricyclic ring system of tricycloclavulone was synthesized from 2-methoxycarbonyl-2-cyclopenten-1-one (2). Key reactions include Lewis acid-catalyzed [2+2]-cycloaddition of a,b-unsaturated ester 2 with thioacetylene derivatives and construction of the A-ring by using the Grubbs catalyst.
Reaction of I-chlon~-2,2-dimethoxyethane with sodium azide affords l -azido-2,2-dimethoxyethane which, upon treatment with triphenylphosphine followed by aromatic aldehydes, alkyl bromides, or isocyanates, gives the corresponding dimethyl a-arylimino-, a-alkylamino-, and a-carbodiimido-acetals, resp