Efficient One-pot Synthesis of Alkyl 3-(alkyl)-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carboxylates in a Multi Component Reaction
β Scribed by Nasir Iravani; Jalal Albadi; Somaieh Varnaseri; Zahra Jaberi; Nahid Karami; Marzieh Khadamati
- Book ID
- 115558635
- Publisher
- Chinese Electronic Periodical Services
- Year
- 2012
- Tongue
- English
- Weight
- 590 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0009-4536
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π SIMILAR VOLUMES
## Abstract The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (=dialkyl butβ2βynedioates) in the presence of silica gel (SiO~2~) led to alkyl 2β(dialkylamino)β4βphenylthiazoleβ5βcarboxylates in fairly high yields. The structures of the products were
Synthesis and Exchange Reactions of 5-Alkyl-2-oxo-6-thioxo-1,2,3,6-Tetrahydropyrimidine-4-carboxylic Acids. -The title compounds are prepared as potential dihydroorotase inhibitors. H/D-exchange studies establish a high tendency towards epimerization at C-5. No epimerization is observed under physi