✦ LIBER ✦

Efficient One-Pot Synthesis of Alkyl 2-(Dialkylamino)-4-phenylthiazole-5-carboxylates and Single-Crystal X-Ray Structure of Methyl 2-(Diisopropylamino)-4-phenylthiazole-5-carboxylate

✍ Scribed by Ali Souldozi; Ali Ramazani; Ali Reza Dadrass; Katarzyna Ślepokura; Tadeusz Lis

Publisher: John Wiley and Sons
Year: 2012
Tongue: German
Weight: 339 KB
Volume: 95
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.201100322

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✦ Synopsis

Abstract

The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylenedicarboxylates (=dialkyl but‐2‐ynedioates) in the presence of silica gel (SiO~2~) led to alkyl 2‐(dialkylamino)‐4‐phenylthiazole‐5‐carboxylates in fairly high yields. The structures of the products were confirmed by their IR, ^1^H‐ and ^13^C‐NMR, and mass spectra, and by a single‐crystal X‐ray structure determination.

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