𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Efficient microwave-assisted synthesis and antioxidant activity of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones

✍ Scribed by Feng Shi; Xiao-Ning Zeng; Fei-Yue Wu; Shu Yan; Wei-Fa Zheng; Shu-Jiang Tu

Publisher
Journal of Heterocyclic Chemistry
Year
2011
Tongue
English
Weight
87 KB
Volume
49
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The efficient synthesis of 4‐arylidene‐2‐phenyl‐1__H__‐imidazol‐5(4__H__)‐ones was achieved via microwave‐assisted reactions of 4‐arylmethylene‐2‐phenyloxazol‐5(4__H__)‐ones with urea in glycol. This approach provides a facile shortcut for the synthesis of this type of compounds with short reaction time, high yields, broad substrate scope and easy operation. Besides, the synthesized compounds were subject to the test of antioxidant activity, which is represented by their capacities for scavenging 1,1‐diphenyl‐2‐picrylhydrazyl, hydroxyl and superoxide anion free radicals. Bioassay of these compounds resulted in the finding of several 4‐arylidene‐2‐phenyl‐1__H__‐imidazol‐5(4__H__)‐ones with significant antioxidant activity. J. Heterocyclic Chem., (2012).

📜 SIMILAR VOLUMES

New cycloaddition reaction between 4-ary
New cycloaddition reaction between 4-arylidene-2-phenyl-5(4H)-1,3-oxazolones and benzyne; facile synthesis of 1,4(H)-benzoxazepine-2-ones and their N-phenyl derivatives
✍ Ashraf A Aly 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 204 KB

Reaction of 4-arylidene-2-phenyl-5(4H)-1,3-oxazolones with benzyne afforded predominantly, 3-arylidene-7-hydroxy-7phenyl-1,4(H)-benzoxazepine-2-ones in addition to their N-phenyl derivatives. However, the reaction of the target oxazolones with an excess of benzyne gave only the N-phenyl derivatives

An Efficient Synthesis of 2,4,5-Trisubst
An Efficient Synthesis of 2,4,5-Trisubstituted and 1,2,4,5-Tetrasubstituted-1H-imidazoles.
✍ Mazaahir Kidwai; Shilpi Saxena; Ruby Ruby; Shweta Rastogi 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 17 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

An efficient microwave-assisted synthesi
An efficient microwave-assisted synthesis of 3,5-unsubstituted 4-substituted-6-aryl-3,4-dihydropyridin-2(1H)-ones derivatives
✍ Shujiang Tu; Xiaotong Zhu; Feng Shi; Jinpeng Zhang; Yan Zhang 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 366 KB

## Abstract magnified image Small libraries of 3,5‐unsubstituted 4‐substituted‐6‐aryl‐3,4‐dihydropyridin‐2(1__H__)‐ones derivatives were synthesized from the condensation‐products of aldehydes with Meldrum's acid, aromatic ketones and ammonium acetate using acetic acid as energy transferring‐agent