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Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector

✍ Scribed by Sakurai, F; Mizuguchi, H; Hayakawa, T


Book ID
110039261
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
178 KB
Volume
10
Category
Article
ISSN
0969-7128

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## Abstract ## Background A paucity of coxsackie adenovirus receptor (CAR) hampers the adenovirus serotype 5 (Ad5)‐based vector‐mediated gene transfer into malignant hematopoietic cells. Fiber‐retargeted adenoviral vectors with species B tropism can potentially bypass the CAR requirement and facil