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Gene transfer into human hematopoietic progenitor cells with an episomal vector carrying an S/MAR element

✍ Scribed by Papapetrou, E P; Ziros, P G; Micheva, I D; Zoumbos, N C; Athanassiadou, A

Book ID
110039676
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
377 KB
Volume
13
Category
Article
ISSN
0969-7128

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## Abstract ## Background A paucity of coxsackie adenovirus receptor (CAR) hampers the adenovirus serotype 5 (Ad5)‐based vector‐mediated gene transfer into malignant hematopoietic cells. Fiber‐retargeted adenoviral vectors with species B tropism can potentially bypass the CAR requirement and facil