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Efficient Formal Total Synthesis of Physostigmine and Physovenine: Conformational Analysis of Key Intermediates 1

✍ Scribed by Morales-Ríos, Martha S.; Santos-Sánchez, Norma F.; Joseph-Nathan, Pedro


Book ID
120190576
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
83 KB
Volume
65
Category
Article
ISSN
0163-3864

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A simple route for the enanrioselective synthesis of key intermediates (11 and 12) for the total synthesis of forskolin has been developed starting from acid 6 and (S)-alcohol 5. The latter is prepared by enantioselective catalytic CBS reduction of dienone 3, and is converted by an intramolecular Di