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Efficient CRISPR-Cas9–mediated genome editing in Plasmodium falciparum

✍ Scribed by Wagner, Jeffrey C; Platt, Randall J; Goldfless, Stephen J; Zhang, Feng; Niles, Jacquin C

Book ID
125844408
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
643 KB
Volume
11
Category
Article
ISSN
1552-4450

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Malaria causes ~660,000 deaths per year, and P. falciparum is the protozoan responsible for its most severe form. The lack of effective vaccines and the parasite's ability to develop drug resistance are major barriers to malaria treatment and eradication. Classical genome manipulation in P. falcipar