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Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

✍ Scribed by Ghorbal, Mehdi; Gorman, Molly; Macpherson, Cameron Ross; Martins, Rafael Miyazawa; Scherf, Artur; Lopez-Rubio, Jose-Juan

Book ID
123621709
Publisher
Nature Publishing Group
Year
2014
Tongue
English
Weight
533 KB
Volume
32
Category
Article
ISSN
1087-0156

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Genome editing in the human malaria para
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
✍ Ghorbal, Mehdi; Gorman, Molly; Macpherson, Cameron Ross; Martins, Rafael Miyazaw πŸ“‚ Article πŸ“… 2014 πŸ› Nature Publishing Group 🌐 English βš– 533 KB

Malaria causes ~660,000 deaths per year, and P. falciparum is the protozoan responsible for its most severe form. The lack of effective vaccines and the parasite's ability to develop drug resistance are major barriers to malaria treatment and eradication. Classical genome manipulation in P. falcipar