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Efficient copper(I)-catalyzed coupling of secondary phosphine oxides with aryl halides

✍ Scribed by Marek Stankevič; Adam Włodarczyk


Book ID
119375838
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
507 KB
Volume
69
Category
Article
ISSN
0040-4020

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An efficient copper-catalyzed coupling o
✍ Ayumu Kiyomori; Jean-François Marcoux; Stephen L. Buchwald 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 230 KB

Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)2°benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 °C. Addition of 1,10-phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylim