An efficient copper-catalyzed coupling o
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Ayumu Kiyomori; Jean-François Marcoux; Stephen L. Buchwald
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Article
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1999
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Elsevier Science
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French
⚖ 230 KB
Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)2°benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 °C. Addition of 1,10-phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylim