Efficient chemoselective synthesis of 3,4′-dihydroxypropiophenone 3-O-β-D-glucoside by thermophilic β-glycosidase fromSulfolobus solfataricus
✍ Scribed by Antonio Trincone; Edoardo Pagnotta
- Book ID
- 104635413
- Publisher
- Springer Netherlands
- Year
- 1995
- Tongue
- English
- Weight
- 290 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0141-5492
No coin nor oath required. For personal study only.
✦ Synopsis
A comparison of different systems for the /3-glycosidase-atalyzed synthesis of 3,4'dihydroxypropiophenone 3-0-/3-D-glucoside is reported including various enzymatic sources and d#erent reaction conditions. The best yield was obtained using thermophilic /3-glycosidase from Sulfolobus solfataricus.
📜 SIMILAR VOLUMES
## Abstract Acetal‐glycosides are a new class of compounds which is of interest in the development of selective anticancer agents. Cytotoxic aldehydes and ketones may be released by enzymatic or acid‐catalyzed hydrolysis preferentially in the tumour tissue. An alternative synthetic route to acetal‐
Methyl 3-O-(3,6-anhydro-beta-D-galactopyranosyl)-alpha-D-galactopyranoside (3) and methyl 3,6-anhydro-4-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside (4) have been synthesised stereoselectively using three coupling procedures. Acceptable yields were achieved using acetylated derivatives as don
A diastereoselective synthesis of b-1-formyl-2,3,4,6-tetra-O-benzyl-D-glucopyranoside in four steps, using an umpolung Seebach reaction is described.