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Efficient Asymmetric Synthesis of (+)-SCH 351448.

✍ Scribed by Sergei Bolshakov; James L. Leighton


Publisher
John Wiley and Sons
Year
2006
Weight
12 KB
Volume
37
Category
Article
ISSN
0931-7597

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## Abstract The monomeric unit of the macrodiolide SCH 351448 has been synthesized from three building blocks. Strategic disconnections were chosen between C21–C22 (Wittig) and C10–C11 (stereoselective aldol). The __cis__ configuration of both 2,6‐disubstituted tetrahydropyran rings was established