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Efficient assembly of a C3 convertase on C3B2-IGG complexes

✍ Scribed by Emiliana Jelezarova; Hans U. Lutz


Book ID
108405355
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
148 KB
Volume
49
Category
Article
ISSN
0162-3109

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A high affinity C5 convertase is generated when a C3 convertase deposits additional C3b molecules on and around itself thereby switching the substrate specificity of C3 convertase from C3 to C5. In the present study the role of the additional C3b molecules in influencing the regulation of classical