Efficient Access to Chiral trans-2,6-Dialkyl-1,2,5,6-tetrahydropyridines via Allylation of Chiral Imines and Ring-Closing Metathesis.
β Scribed by Francois-Xavier Felpin; Jacques Lebreton
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 145 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Treatment of salts 1a-b with Grignard reagents gives, after reduction of the resulting unstable dihydropyridines 7, the tetrahydropyridines 8a-c, with modest selectivities but in very few steps and under practical conditions. Higher stereoand regioselectivities are obtained with salt 1c which gives
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