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Efficiency of carcinogenesis: Is the mutator phenotype inevitable?

✍ Scribed by Robert A. Beckman


Book ID
113900481
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
366 KB
Volume
20
Category
Article
ISSN
1044-579X

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Multistage models of carcinogenesis that include death and mutation of target cells at risk for cancer, but do not include cell division, may be appropriate for cancers in which clonal expansion arises downstream of the rate-determining step toward carcinogenesis. Such models are simpler than clona