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Overexpression of cyclin E protein is closely related to the mutator phenotype of colorectal carcinoma

✍ Scribed by Debniak, Tadeusz; Giannakudis, Joannis; Hoang-Vu, Cuong; Dralle, Henning; Sutter, Thomas; Dansranjavin, Temuujin; Lubinski, Jan

Book ID: 113036849
Publisher: Springer
Year: 2002
Tongue: English
Weight: 218 KB
Volume: 17
Category: Article
ISSN: 0179-1958
DOI: 10.1007/s00384-002-0390-y

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio