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Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial

✍ Scribed by Werner H Poewe; Olivier Rascol; Niall Quinn; Eduardo Tolosa; Wolfgang H Oertel; Emilia Martignoni; Markus Rupp; Babak Boroojerdi


Book ID
114408627
Publisher
The Lancet
Year
2007
Tongue
English
Weight
165 KB
Volume
6
Category
Article
ISSN
1474-4465

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## Abstract Rotigotine is a new, non‐ergot dopamine agonist formulated in a transdermal delivery system. The present study was to investigate the efficacy and safety of the rotigotine transdermal patch in the treatment of early Parkinson's disease. Patients (n = 561) were randomized to rotigotine,

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## Abstract We compared the efficacy and safety of pramipexole (PPX) with placebo in the treatment of advanced Parkinson's disease (PD) as an adjunct to levodopa. A bromocriptine (BR) group was included to enable determination of the noninferiority of PPX relative to BR as the standard treatment. Β©