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Efficacy of long term lamivudine therapy in HBeAg negative chronic hepatitis B

✍ Scribed by Dimou, Evangelini; Papatheodoridis, George V.; Laras, Andreas; Hadziyannis, Stephanos J.

Book ID
122410270
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
189 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract Hepatitis B e antigen (HBeAg)‐negative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7–30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia.

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One year of lamivudine treatment results in increased hepatitis B e antigen (HBeAg) seroconversion and serum hepatitis B virus (HBV) DNA negativity in children with chronic hepatitis B and high serum alanine aminotransferase concentrations. Two hundred seventy-six children who participated in a 1-ye