Efficacy of long term lamivudine therapy in HBeAg negative chronic hepatitis B
β Scribed by E. Dimou; G.V. Papatheodoridis; A. Laras; S.J. Hadziyannis
- Book ID
- 119526044
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 148 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0168-8278
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## Abstract Hepatitis B e antigen (HBeAg)βnegative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7β30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia.
One year of lamivudine treatment results in increased hepatitis B e antigen (HBeAg) seroconversion and serum hepatitis B virus (HBV) DNA negativity in children with chronic hepatitis B and high serum alanine aminotransferase concentrations. Two hundred seventy-six children who participated in a 1-ye