✦ LIBER ✦

Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors

✍ Scribed by Luca Rozzini; Daniela Costardi; Barbara Vicini Chilovi; Simone Franzoni; Marco Trabucchi; Alessandro Padovani

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 86 KB
Volume: 22
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.1681

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Individuals who have Mild Cognitive Impairment (MCI) may be in a transitional stage between aging and Alzheimer's disease (AD). The high rate of conversion from MCI to AD makes early treatment an important clinical issue. Recent evidence suggests that cognitive training intervention may reduce the rate of progression to AD.

Objectives

To evaluate the efficacy of a NeuroPsychological Training (TNP) in patients with MCI who are treated with cholinesterase inhibitors (ChEIs), compared with patients MCI treated only with ChEIs and patients not treated, in a longitudinal, one year follow‐up study.

Methods

One year longitudinal and retrospective comparison study of neuropsychological performances in 59 subjects affected by Mild Cognitive Impairment (MCI) according to Petersen's criteria. Fifteen subjects were randomised to receive TNP plus cholinesterase inhibitors; 22 subjects cholinesterase inhibitors alone and 22 subjects no treatment. All the subjects referring memory complaints, corroborated by an informant, underwent a multidimensional assessment concerning neuropsychological, behavioural and functional characteristics, at baseline and after one year follow‐up.

Results

Subjects without treatment maintained their cognitive, functional and behavioural status after one year; patients treated only with ChEIs improved in depressive symptoms whereas subjects treated with TNP and ChEIs showed significant improvements in different cognitive areas, such as memory, abstract reasoning and in behavioural disturbances, particularly depressive symptoms.

Conclusions

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