Effects of β2–microglobulin mutations on the alpha-1 helical region of H2-Ld
✍ Scribed by Carla S. Schultz; Rafael A. Rodriguez; Eleanor A. Chew; Christian Dimaano; Fung-Mee Li; Marjorie D. Santos; M. C. Nieto
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 499 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0093-7711
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Peptide recognition by class I products of the major histocompatibility complex requires association of the class I heavy chain with β~2~‐microglobulin. We present results of Monte Carlo simulations of the β‐pleated sheet floor of the human class I MHC molecule, HLA‐A2, with and without
Introduction of the MHC class I transgene H-2D d on C57BL/6 (B6) background conveys NK cell-mediated "missing self" reactivity against transgene-negative cells, and down-regulates expression of the inhibitory receptors Ly49A and Ly49G2 in NK cells. We here present an analysis of transgenic mice expr