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Effects of α-Difluoromethylornithine-Induced Polyamine Depletion on the Radiosensitivity of a Human Colon Carcinoma Cell Line

✍ Scribed by Carla M. Arundel, Kenji Nishioka and Philip J. Tofilon

Book ID
124656640
Publisher
Bioone
Year
1988
Tongue
English
Weight
769 KB
Volume
114
Category
Article
ISSN
0033-7587

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We investigated the effect of pretreatment with difluoromethylornithine (DFMO), an ornithine decarboxylase inhibitor, on the cytocidal responses of four human adenocarcinoma cell lines to two alkylating and crosslinking agents: chlorambucil and N,N',N"-triethylenethiophosphoramide (thiotepa). The ce