Effects of water temperature and weight of wheel load on water wheel turning behavior of imipramine administered mice

✍ Scribed by Jun Shimizu; Soichiro Nomura; Hiroko Kuno; Tsuneyuki Nakazawa

• Book ID: 104771596
• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 209 KB
• Volume: 84
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00432017

✦ Synopsis

This experiment investigated the effect of imipramine on water wheel turning behavior in relation to the water temperature and the wheel load. It was shown that the higher the water temperature, the more the mice rotated the wheel, and the greater the wheel load, the less mice rotated it. However, these factors did not reduce the effect of imipramine, which increased the number of responses. It was suggested that the water wheel test shows promise as a screening test for antidepressants.