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Effects of von Hippel-Lindau gene mutation and methylation status on expression of transmembrane carbonic anhydrases in renal cell carcinoma

✍ Scribed by Shingo Ashida; Isao Nishimori; Masanobu Tanimura; Saburo Onishi; Taro Shuin


Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
613 KB
Volume
128
Category
Article
ISSN
1432-1335

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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R