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Effects of verapamil on the cellular accumulations and toxicity of several antitumor drugs in 9-hydroxy-ellipticine-resistant cells

โœ Scribed by Charlotte Delaporte; Jean-Yves Charcosset; Alain Jacquemin-Sablon


Book ID
115780169
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
841 KB
Volume
37
Category
Article
ISSN
0006-2952

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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra