Effects of cyclosporin a and verapamil o
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M. H. Silbermann; A. W. M. Boersma; A. L. W. Jamssen; R. J. Scheper; H. Herweije
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Article
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1989
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John Wiley and Sons
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French
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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra