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Effects of cytochalasins and colchicine on the accumulation and retention of daunomycin and vincristine in drug resistant tumor cells

✍ Scribed by Takashi Tsuruo; Harumi Iida

Book ID
115778810
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
437 KB
Volume
35
Category
Article
ISSN
0006-2952

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Effects of verapamil enantiomers and maj
Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines
✍ K. HΓ€ußermann; B. Benz; V. Gekeler; K. Schumacher; M. Eichelbaum πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 854 KB

Verapamil, a calcium channel blocker, is used as the racemate. Recently, racemic verapamil has been shown to increase the cytotoxicity of vinca alkaloid and anthracycline derivatives in several resistant tumour cell lines. With respect to its cardiovascular activity S-verapamil is an order of magnit