Effects of varying oxygen tension on mortality of X-rayed mice

• Publisher: Elsevier Science
• Year: 1950
• Tongue: English
• Weight: 120 KB
• Volume: 249
• Category: Article
• ISSN: 0016-0032
• DOI: 10.1016/0016-0032(50)90442-x

✦ Synopsis

Effects of Varying Oxygen Tension on Mortality of X-Rayed Mice.--GEORGE LIMPEROS. The mortality of mice exposed to x-radiation was found to be reduced by thiourea (5) possibly because of its anti-thyroid activity. Blount et al (1) reported that desiccated thyroid increased the mortality of mice exposed to x-radiation and also increased oxygen consumption by 40 per cent. The increase in oxidative metabolism has been suggested by Smith et al as the factor responsible for the increase in mortality of mice exposed to x-radiation at a low environmental temperature. Increasing the oxygen tension might, therefore, increase the mortality of mice exposed to x-radiation and, conversely, reducing the oxygen tension might reduce mortality. The results of preliminary experiments are reported at this time.

Male, white mice (Detwiler) weighing 18-22 g. were allowed Fox Food Blox (Allied Mills) and water ad libiturn. The mice were irradiated in groups of 15 with 500 r given at a rate of 74 r/rain. The 'l'am.E l.--Effect of Increased and Decreased Oxygen Tension on the Mortality of Mice X-Rayed with 500 r.