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Effects of ulapualide A and synthetic macrolide analogues on actin dynamics and gene regulation

โœ Scribed by E. Vincent; J. Saxton; C. Baker-Glenn; I. Moal; J. D. Hirst; G. Pattenden; P. E. Shaw


Book ID
105758511
Publisher
Springer
Year
2007
Tongue
English
Weight
1014 KB
Volume
64
Category
Article
ISSN
1420-682X

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The C11-C22 and C23-C35 segments 2 and 3 of reidispongiolide A (1), an actin-depolymerizing marine macrolide, were synthesized enantioselectively in 12 steps from (R)-glycidyl trityl ether and in 12 steps from chiral ketone 15, respectively.