Effects of transforming growth factor-β1on formation and activation of osteoclasts
✍ Scribed by Hiroshi Kamioka; Keishi Ishikawa; Kayo Tanaka; Takuya Sato; Ken-Ichi Tezuka; Kenji Hiura; Koji Sumitani; Yoshiyuki Hakeda; Terushige Kawata; Masayoshi Kumegawa
- Book ID
- 105305507
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 957 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0914-8779
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Transforming growth factor-beta1 (TGF-beta) is secreted in a latent form consisting of mature TGF-beta noncovalently associated with its amino-terminal propeptide, which is called latency associated peptide (LAP). Biological activity depends upon the release of TGF-beta from the latent complex follo
The effect of transforming growth factor-pl (TGFP1) on three developmental stages of megakaryocytopoiesis was investigated. Using a murine bone marrow agar culture system, titrated doses of TGFPl were added to cultures assaying primitive high pro1 iferative megakaryocyte progenitors, committed megak
At first reading the statement "TCFP stimulates bone formation but inhibits mineralization" may appear to be an oxymoron. However, the bone formation process can take weeks to months to complete, and the unique properties of TGFP allow this factor to be stored in bone matrix in a latent form, ready