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Effects of transforming growth factor-β1 and interleukin-1α on matrix synthesis in osteoarthritic cartilage of the temporo-mandibular joint in aged mice

✍ Scribed by I Blumenfeld; D Laufer; E Livne


Book ID
119484931
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
379 KB
Volume
95
Category
Article
ISSN
0047-6374

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Osteoarthritis in the temporo-mandibular
✍ Livne, Erella; Laufer, Dov; Blumenfeld, Israel 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 571 KB

The temporo-mandibular joint of aged mice develops osteoarthritic (OA) degenerative lesions. Adult chondrocytes have a low rate of cell replication, and cartilage repair potential is very limited. One of the major problems in OA is the low rate of matrix synthesis and the inability of the chondrocyt