Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice
โ Scribed by Toshitaka Nabeshima; Shigeru Yoshida; Tsutomu Kameyama
- Book ID
- 115881411
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 517 KB
- Volume
- 154
- Category
- Article
- ISSN
- 0014-2999
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Mice given one-triM passive avoidance training were examined 24 hours later for retention of the acquired response. Testing was carried out with subjects given either ehlorpromazine or saline injections before the test session. Three chlorpromazine doses (0.5, 2.0, and 3.5 mg]kg) were used, and thre
In mice with procephalic ischaemia loading, disrupted passive avoidance retention performance was dose-dependently improved by Choto-san, but this effect was antagonized by NAN-190, a serotonin 1A receptor antagonist. In mice with decreased intracerebral serotonin concentration, Choto-san prevented