I n rats, the effects of an intracerebroventricular (ICV) nicotinic agonist nicotine (NIC), the nicotinic antagonist mecamylamine (MEC), and combinations of NIC + MEC were assessed in a radial-arm maze (RAM). In experiment 1, exploratory behavior was assessed in untrained rats (N = 13). The rats rec
โฆ LIBER โฆ
Effects of the nicotinic receptor blocker mecamylamine on radial-arm maze performance in rats
โ Scribed by Edward D. Levin; Mark Castonguay; Gaylord D. Ellison
- Book ID
- 119505564
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 439 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0163-1047
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Nicotine and other nicotinic agonists have been found to improve performance in a variety of tasks, including the radial-arm maze to improve memory. There has been an active effort to develop novel nicotinic agonists for the treatment of cognitive dysfunction such as is seen in Alzheimer's disease.