Effects of the JAK2 mutation on the hematopoietic stem and progenitor compartment in human myeloproliferative neoplasms
β Scribed by Anand, S.; Stedham, F.; Beer, P.; Gudgin, E.; Ortmann, C. A.; Bench, A.; Erber, W.; Green, A. R.; Huntly, B. J. P.
- Book ID
- 121685514
- Publisher
- American Society of Hematology
- Year
- 2011
- Tongue
- English
- Weight
- 363 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0006-4971
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## Abstract __Background__: Several methods have been established to detect the JAK2 V617F mutation, a frequent event involved in the pathogenesis of myeloproliferative neoplasms (MPNs). Highβresolution melt (HRM) analysis is a newly established technique without the requirement of any gelβbased po
## Abstract Evolution to myelofibrosis (MF), acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) may occur over time in myeloproliferative neoplasms (MPN) patients most likely due to the acquisition of additional mutations. The Groupe Francophone de cytogenetique hematologique (GFCH) has c