Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms

Chromosomal abnormalities in transformed

Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations

✍ Florence Nguyen-Khac; Claude Lesty; Virginie Eclache; Lucile Couronné; Olivier K 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 208 KB

## Abstract Evolution to myelofibrosis (MF), acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) may occur over time in myeloproliferative neoplasms (MPN) patients most likely due to the acquisition of additional mutations. The Groupe Francophone de cytogenetique hematologique (GFCH) has c