Effects of the differentiated keratinocyte phenotype on expression levels of CYP1–4 family genes in human skin cells
✍ Scribed by Liping Du; Mark M. Neis; Patricia A. Ladd; Diane L. Lanza; Garold S. Yost; Diane S. Keeney
- Book ID
- 113923815
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 448 KB
- Volume
- 213
- Category
- Article
- ISSN
- 0041-008X
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The influence of cell density and epidermal growth factor (EGF) on the expression and inducibility of cytochrome P450 (CYP) genes of the CYP3A and CYP1A families in adult human hepatocytes in primary culture has been evaluated. Only when cultured at subconfluence and in the presence of EGF did hepat
## Abstract Rac1 is a Rho subfamily small GTPase which is highly expressed in epidermal keratinocytes. In mice the significance of Rac1 for the maintenance of the epidermis has been controversial. In keratinocytes from human origin, the role of Rac1 in the control of growth/differentiation is still