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Effects of temperature on the interaction of dihydrofolate reductase with some of its ligands

โœ Scribed by R. Gilli; S. Sasso; C. Lopez; C. Briand; J.C. Sari

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
506 KB
Volume
204
Category
Article
ISSN
0040-6031

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Monitoring the effect of triamterene and
Monitoring the effect of triamterene and hydrochlorothiazide on dihydrofolate reductase activity using a new spectrophotometric method
โœ Madiha B. Sidhom; Miriam R. Velez ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 407 KB

A new spectrophotometric method is developed and applied for the study of the inhibitory effect of triamterene, hydrochlorothiazide and their combinations on the in vitro activity of dihydrofolate reductase enzyme. The method is based on incubating the drug (0.1-1.0 microM) or a buffer control with