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Effects of surface undulations of biphasic calcium phosphate tablets on human osteoblast behavior

✍ Scribed by Euler A. dos Santos; Adriana B. R. Linhares; Alexandre M. Rossi; Marcos Farina; Gloria A. Soares

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
513 KB
Volume
74A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

In this work, the in vitro behavior of human osteoblast cells on the undulated surfaces of biphasic calcium phosphate tablets was investigated. The tablets were produced by uniaxial pressing with convex cylindrical undulations occupying only half of the surface area; the other half was flat. Chemical and physical characterization was performed by scanning electron microscopy (SEM), atomic force microscopy (AFM), X‐ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). XRD and FTIR analyses revealed the presence of hydroxyapatite (HA) and α‐tricalcium phosphate (α‐TCP) in a well‐defined ratio. Moreover, microtopography, evaluated by SEM and AFM, was similar on the flat region and on that with undulations. However, surface undulations induced different cellular arrangements, confirming the influence of the macrotopography on the cells orientation. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005

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