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Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3 H ,4 H -2,6-dioxa-4- azacyclopenta[ b ]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium Channel Opener

✍ Scribed by Altenbach, Robert J.; Brune, Michael E.; Buckner, Steven A.; Coghlan, Michael J.; Daza, Anthony V.; Fabiyi, Adebola; Gopalakrishnan, Murali; Henry, Rodger F.; Khilevich, Albert; Kort, Michael E.; Milicic, Ivan; Scott, Victoria E.; Smith, Jamie C.; Whiteaker, Kristi L.; Carroll, William A.


Book ID
120436621
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
281 KB
Volume
49
Category
Article
ISSN
0022-2623

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✍ Marina Orešić; Aleksandar Danilovski; Miljenko Dumić; Nada Košutić-Hulita 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 100 KB

## Abstract By heating 2‐chloromethyl‐3,‐5‐dimethyl‐4‐methoxypyridine **(1)** either neat or in solution methoxy group cleavage was achieved, followed by dimerisation to poorly soluble 6,12‐dihydro‐1,3,7,9‐tetramethyl‐5__H__,11__H__‐dipyrido[1,2‐a:1′,2′‐d]pyrazine‐2,8‐dione **(3)** in almost quanti